What Separates Us follows Danny (Bryan Ferriter) as he seems ready to commit to the austere existence provided to him after the death of his parents. He lives for his friends and the whiskey fueled rush of a midday brawl until he meets Parker (Shannon Mary Dixon), an art student at the local college. Their relationship forces Danny to take a hard look at his life and weigh the balance between his support system and the pursuit of his dreams.

A man raised in complete isolation his entire life is released into society for the first time as an adult and must learn how to live. Along the way, he discovers that he's part of a social experiment and sets off to find answers about his dark past.